- Research Scientist
- Environmental Toxicology & Chemistry Laboratory
- Great Lakes Center
- SUNY College at Buffalo
- Science Building 267
- Buffalo, New York 14222
- Telephone: 716-878-4614
- Fax: 716-878-5400
- E-mail: mukherjj@buffalostate.edu
EDUCATION:
1982: Ph.D; Biochemistry, Calcutta University, India
1973: M.Sc.; Biochemistry, Calcutta University, India
1971: B.Sc.; Chemistry, Calcutta University, India
RESEARCH INTERESTS:
Carcinogenesis; Signal transduction; Toxicology
GRANTS/CONTRACTS RECEIVED:
2008-2011: Phenolic component of tobacco smoke as tumor promoter. National Institute of Health
2000-2005: Attenuation of p53 Response to PAHs by Tumor Promoters. National Institute of Health
REVIEWED PUBLICATIONS:
Mukherjee J.J., Gupta, S.K. and Kumar, S. 2009. Inhibition of benzopyrene-diol-epoxide (BPDE)-induced bax and caspase-9 by cadmium: Role of mitogen activated protein kinase. Mutation Research, 661: 41-46.
Mukherjee J.J., Gupta, S.K. and Kumar, S. 2008. Inhibition of benzopyrene diol epoxide-induced apoptosis by cadmium (II) is AP-1-independent: Role of extracellular signal related kinase. Chem. Biol. Interact., 172:72-80.
Mukherjee J.J. and Sikka, H.C. 2005. Attenuation of BPDE-induced p53 accumulation by TPA is associated with adecrease in stability and phosphorylation of p53 and down-regulation of NF [[kappa]]B activation: Role of p38 MAP kinase. Carcinogenesis, 27: 631-638.
Mukherjee J.J. and Sikka, H.C. 2005. Mechanism of attenuation of benzo[a]pyrene-7,8-diol-9,10-epoxide (anti-BPDE)-induced p53 response by 12-O-tetradecanoylphorbol-13-acetate. Proc. Amer. Assoc. Cancer Res. 46: 278.
Veeraghavan, M., Gupta, S.K., Mukherjee, J. J., Kumar, S., Wani, A.and Sikka, H.C. 2005. Age-associated changes in cellular response to (anti)-benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) in human fibroblasts. Proc. Amer. Assoc. Cancer Res. 46: 279.
Gupta, S.K., Veeraghavan, M., Mukherjee, J. J., Kumar, S. and Sikka, H.C. 2005. Comparative effects of naturally occurring chemopreventive compounds on metastasis-related events in HT-1080 cells. Proc. Amer. Assoc. Cancer Res. 46: 578.
Mukherjee, J.J., Gupta, S.K., Kumar, S., Sikka, H.C. 2004. Effects of cadmium(II) on (+/-)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide-induced DNA damage response in human fibroblasts and DNA repair: a possible mechanism of cadmium’s cogenotoxicity. Chem. Res. Toxicol. 17: 287-293.
Mukherjee, J.J., Gupta, S.K., Kumar, S. and Sikka, H.C. 2003. Effects of Cd2+ and Ni2+ on cellular response to benzo[a]pyrene-induced DNA damage. Proc. Amer. Assoc. Cancer Res. 44(2nded.): 83.
Gupta, S.K., Mukherjee, J. J., Kumar, S., McGarrigle, B., Olson, J.R., and Sikka, H.C. 2003. Effect of postnatal development on the metabolism of benzo(a)pyrene by rat and human liver microsomes. Proc. Amer. Assoc. Cancer Res. 44(2nded.): 294.
Mukherjee, J.J., S.K. Gupta, S. Kumar, and H.C. Sikka. 2003. Effects of cadmium(II) on (+/-)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide-induced DNA damage response in human fibrolasts and DNA repair: a possible mechanism of camium’s co-genotoxicity. Chem. Res. Toxicol.
She, Q.B., Mukherjee JJ, Chung, T and Kiss, Z. 2000. Placental alkaline phosphatase, insulin, and adenine nucleotides or adenosine synergistically promote long-term survival of serum-starved mouse embryo and human fetus fibroblasts. Cell Signal 12: 659-65.
She, QB., Mukherjee J.J., Crilly, KS and Kiss, Z. 2000. Alpha(1)-antitrypsin can increase insulin-induced mitogenesis in various fibroblast and epithelial cell lines. FEBS Letters 473: 33-36.
She, QB., Mukherjee J.J., Huang, J-S., Crilly KS and Kiss Z. 2000. Growth factor-like effects of placental alkaline phosphatase in human fetus and mouse embryo fibroblasts. FEBS Letters 469: 163-167.
Chung, TW., Huang, J-S., Mukherjee J.J., Crilly, KS and Kiss, Z. 2000. Expression of human choline kinase in NIH 3T3 fibroblasts increases the mitogenic potential of insulin and insulin-like growth factor I. Cellular Signalling 12: 279-288.
Huang, J-S., Mukherjee, J.J., Chung, T., Crilly, KS and Kiss Z. 1999. Extracellular calcium stimulates DNA synthesis in synergism with zinc, insulin and insulin-like growth factor I in fibroblasts. European Journal of Biochemistry 266: 943-951.
She, QB., Huang, J-S., Mukherjee J.J., Crilly, KS and Kiss, Z. 1999. The possible mechanism of synergistic effects of ethanol, zinc and insulin on DNA synthesis in NIH 3T3 fibroblasts. FEBS Letters 460(2): 199-202.
Huang, J-S., Mukherjee, J.J., and Kiss Z. 1999. Ethanol potentiates the mitogenic effects of sphingosine-1-phosphate by a zinc and calcium-dependent mechanism in fibroblasts. Arch. Biochem. Biophys. 366: 131-138.
Mukherjee, J.J., Huang, J-S., Getman, C. and Kiss Z. 1999. Bombesin promotes synergistic stimulation of DNA synthesis by ethanol and insulin in fibroblasts. Arch. Biochem. Biophys.362: 183-189.
Malewicz, B., Mukherjee, J.J., Crilly, K.S., Baumann, W.J. and Kiss, Z. 1998. Phosphorylation of ethanolamine,methylethanolamine, and imethylethanolamine by overexpressed ethanolamine kinase in NIH 3T3 cells decreases the co-mitogenic effects of ethanolamines and promotes cell survival. Eur. Journal of Biochem. 253: 10-19.
Kiss, Z., Anderson, W.H. and Mukherjee, J.J. 1998. Ethanol potentiates the stimulatory effects of insulin and phosphocholine on mitogenesis by a zinc-dependent and rapamycin-sensitive mechanism in fibroblasts and JB6 cells. Biochemical Journal 330: 819-826.
Kiss, Z., Mukherjee, J.J., Crilly, K.S. and Chung, T. 1997. Ethanolamine, but not phosphoethanolamine, potentiates the effects of insulin, phosphocholine, and ATP on DNA synthesis in NIH 3T3 cells: Role of mitogen-activated protein-kinase-dependent and independent mechanisms. Eur. Journal of Biochemistry 250: 395-402.
Kiss, Z. and Mukherjee, J.J. 1997. Phosphocholine and sphingosine-1-phosphate synergistically stimulate DNA synthesis by a MAP kinase-dependent mechanism. FEBS Letters 412: 197-200.
Chung, T., Crilly, K.S., Anderson, W.H., Mukherjee, J.J. and Kiss, Z. 1997. ATP-dependent choline phosphate-induced mitogenesis in fibroblasts involves activation of pp70S6 kinase and phosphatidylinositol 3’-kinase through an extracellular site: Synergistic mitogenic effects of choline phosphate and sphingosine-1-phosphate. Journal of Biological Chemistry 272: 3064-3072.
Mukherjee, J.J.., Chung, Taeowan, Ways D. Kirk and Kiss , Z. 1996. Protein kinase C-a is a major mediator of the stimulatory effect of phorbol ester on phospholipase D-mediated hydrolysis of phosphatidylethanolamine. Journal of Biological Chemistry 271: 28912-28917.
Mukherjee, J.J., Jay, F.T. and Choy, P.C. 1993. Purification, characterization and modulation of a microsomal carboxylesterase in rat liver for the hydrolysis of acyl-CoA. Biochemical Journal 295: 81-86.
Mukherjee, J.J. and Dekker, E.E. 1992. Inactivation of E.coli 2-Amino-3-ketobutyrate (AKB) CoA ligase by phenylglyoxal and identification of an active site arginine peptide. Arch Biochem. Biophys. 299: 147-153.
Tardi, P.G., Mukherjee, J.J. and Choy, P.C. 1992. The quantitation of long chain acyl-CoA in rat liver. Lipids 27: 65-67.
Mukherjee, J.J., Tardi, P.G. and Choy, P.C. 1992. Solubilization and modulation of Acyl-CoA:1-acyl-glycerophosphocholine acyltransferase activity in rat liver microsomes. Biochim. Biophys. Acta. 1123: 27-32.
Choy, P.C., Tardi, P.G. and Mukherjee, J.J. 1992. Lysophosphatidylcholine:acyl CoA acyltransferase. Methods in Enzymology 209: 80-86.
Mukherjee, J.J. and Dekker, E.E. 1990. 2-Amino-3-ketobutyrate (AKB) CoA ligase of Escherichia coli: Stoichiometry of pyridoxal phosphate binding and location of the pyridoxyllysine peptide in the primary structure of the enzyme. Biochim. Biophys. Acta. 1037: 24-29.
Mukherjee, J.J. and Dekker, E.E. 1988. 2-Amino-3-ketobutyrate (AKB) CoA ligase of E. coli: Pyridoxal phosphate (PLP) stoichiometry of binding and amino acid sequence of the pyridoxyllysine peptide. The FASEB Journal 2: A1747. Mukherjee, J.J. and Dekker, E.E. 1987. Purification, properties and N-terminal amino acid sequence of homogeneous Escherichia coli 2-amino-3-ketobutyrate CoA ligase, a pyridoxal phosphate-dependent enzyme. Journal of Biological Chemistry 262: 14441-14447.
Mukherjee, J.J. and Dekker E.E. 1986. 2-Amino-3-ketobutyrate (AKB) CoA ligase of E. coli: A dimeric pyridoxal phosphate (PLP)- dependent enzyme. Fed. Proc. 45: 1740
Mukherjee, J.J. and Pal, P.R. 1983. Studies on multiple forms of inorganic pyrophosphatase from the leaf of Amarantus blitum L. Agric. Biol. Chem. 47: 2973-2975.
Mukherjee, J.J. and Pal, P.R. 1983. An alkaline magnesium-dependent inorganic pyrophosphatase from the leaf of Amarantus blitum L. Agric. Biol. Chem. 47: 1341-1344.
Mukherjee, J.J. and Pal, P.R. 1983. Studies on inorganic pyrophosphatase in germinating Phaseolus aureus seeds. IRCS Med. Sci. (England), 11: 963-964.
Mukherjee, J.J. and Pal, P.R. 1982. Distribution of alkaline pyrophosphatase in different family of plants and partial characterization from Amarantus blitum L. Agric. Biol. Chem. 46: 2735-2740.
Mukherjee J.J. and Pal, P.R. 1981. Inorganic pyrophosphatase in leaves of Cynodon dactylon pers. Current Science 50: 1027-1028.
Bhattacharya, S.K., Mukherjee, J.J. and Basu, A. 1981. Nutritive value of Chhang, an indigenous Millet-Beer of the Sherpas. Applied Nutrition 9: 39-41.
MANUSCRIPTS REVIEWED FOR:
Journal of the National Cancer Institute
